Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis

UCSF Pepper Center Scholar Alumni, Drs. Sara LaHue and Jen Lai, collaborated with Dr. John Newman to publish an article in GeroScience entitled "Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis". Frailty is an important predictor of mortality and clinical outcomes in adults with cirrhosis even though these patients are relatively young while frailty is classically associated with advanced age. Thus, they aimed to investigate whether accelerated biological age, specifically PhenoAge AgeAccel, is associated with frailty and other clinical outcomes in a feasibility pilot of adults with cirrhosis undergoing liver transplantation. They then explored the consistency of our findings across four commonly used epigenetic clocks spanning both first- and second-generation methodologies.